Exploration of β-turn scaffolding motifs as components of sialyl Le(x) mimetics and their relevance to P-selectin

DOI: 10.1016/S0960-894X(98)00500-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2803 - 2808 (1998)

Update date:2022-08-03

Topics:

Authors:

Hanessian, Stephen

Huynh, Hoan K.

Reddy, Gurijala V.

McNaughton-Smith, Grant

Ernst, Beat

Kolb, Hartmuth C.

Magnani, John

Sweeley, Charla

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00500-9

Monocyclic and bicyclic lactam units representing β-turn surrogate were incorporated into a sialyl Le(x) structure by replacement of the natural sugar components. Low micromolar activity was found in a new P-selectin binding assay.

Full text of DOI:10.1016/S0960-894X(98)00500-9

Products guided by the article

Product name:2,2-Dimethyl-propionic acid (2R,3S,4S,5R,6S)-3,4,5-triacetoxy-6-[(3S,6S,8S,8aS)-8-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-5-oxo-octahydro-indolizin-6-yloxy]-tetrahydro-pyran-2-ylmethyl ester

Cas No:218792-61-1

R&D Labs maybe for 218792-61-1

Shijiazhuang Haotian Chemical Co., Ltd.

Contact:86-311-85044374

Address:293 Donggang Road
Shanghai Hanhong Scientific Co.,Ltd.

website:http://www.chemvia.com

Contact:+86-21-64541543,54280654,13918533501

Address:Jiachuan Road 245
Hotechem Shanghai Co., Ltd

Contact:13120882795；+86-21-34621078;+86-021-31122318

Address:Suite 2,No.2715 Longwu Road
Changsha Goomoo Chemical Technology Co.Ltd

Contact:+86-731-82197655

Address:No.649,Chezhan Rd.(N),Changsha,Hunan,China
Penglai Qianwei Chemical Co., Ltd.

Contact:86-535-3357802

Address:Shahelu (north), Penglai, Shandong, China

Relevant to this article

Chemoselective reduction of a lactam carbonyl group in the presence of a gem-dicarboxylate by sodium borohydride and iodine: A facile entry to N-aryl trisubstituted pyrroles

Doi:10.1016/j.tetlet.2003.09.085
(2003)
Remote asymmetric induction in Michael additions of allylic sulfones

Doi:10.1021/jo982004g
(1999)
ω-Substituted alkyl carboxylic acids as antidiabetic and lipid-lowering agents

Doi:10.1016/S0223-5234(99)80029-4
(1998)
Tuning the Selectivity of AuPd Nanoalloys towards Selective Dehydrogenative Alkyne Silylation

Doi:10.1002/chem.201900493
(2019)
A synthesis of the ring system of terpestacin

Doi:10.1016/S0040-4039(98)02535-0
(1999)
Field-Induced Slow Magnetic Relaxation and Gas Adsorption Properties of a Bifunctional Cobalt(II) Compound

Doi:10.1021/acs.inorgchem.5b02324
(2015)

Article Doi