Exploration of β-turn scaffolding motifs as components of sialyl Le(x) mimetics and their relevance to P-selectin

DOI: 10.1016/S0960-894X(98)00500-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2803 - 2808 (1998)

Update date:2022-08-03

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Authors:

Hanessian, Stephen

Huynh, Hoan K.

Reddy, Gurijala V.

McNaughton-Smith, Grant

Ernst, Beat

Kolb, Hartmuth C.

Magnani, John

Sweeley, Charla

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Article abstract of DOI:10.1016/S0960-894X(98)00500-9

Monocyclic and bicyclic lactam units representing β-turn surrogate were incorporated into a sialyl Le(x) structure by replacement of the natural sugar components. Low micromolar activity was found in a new P-selectin binding assay.

Full text of DOI:10.1016/S0960-894X(98)00500-9

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