Studies in marine macrolide synthesis: Synthesis of a fully functionalised C1-C28 subunit of spongistatin 1 (Altohyrtin A)

Article abstract of DOI:10.1016/S0040-4039(98)01908-X

The C₁-C₂₈ aldehyde 5, containing the AB- and CD-spiroacetal portions together with the bridging chain of spongistatin 1 (1), was prepared. The key step was a lithium-mediated, anti-aldol coupling between ethyl ketone 4 and aldehyde