Pyrroles and other heterocycles as inhibitors of P38 kinase

DOI: 10.1016/S0960-894X(98)00495-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2689 - 2694 (1998)

Update date:2022-08-05

Topics:

Authors:

De Laszlo, Stephen E.

Visco, Denise

Agarwal, Lily

Chang, Linda

Chin, Jayne

Croft, Gist

Forsyth, Amy

Fletcher, Daniel

Frantz, Betsy

Hacker, Candice

Hanlon, William

Harper, Coral

Kostura, Matthew

Li, Bing

Luell, Sylvie

MacCoss, Malcolm

Mantlo, Nathan

O'Neill, Edward A.

Orevillo, Chad

Pang, Margaret

Parsons, Janey

Rolando, Anna

Sahly, Yousif

Sidler, Kelley

Widmer, W. Rick

O'Keefe, Stephen J.

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Article abstract of DOI:10.1016/S0960-894X(98)00495-8

Investigation of furans, pyrroles and pyrazolones identified 3-pyridyl- 2,5-diaryl-pyrroles as potent, orally bioavailable inhibitors of p38 kinase. 3-(4-pyridyl-2-(4-fluoro-phenyl)-5-(4-methylsulfinylphenyl)-pyrrole (L- 167307)) reduces secondary paw swe

Full text of DOI:10.1016/S0960-894X(98)00495-8

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