
Tetrahedron p. 14549 - 14564 (1998)
Update date:2022-08-03
Topics:
Pansare, Sunil V.
Ravi, R. Gnana
N-Acylation of prolinol with α-ketoacid chlorides results in concomitant hemiacetalization of the α-keto amide by the prolinol hydroxyl group. (R) or (S) α-hydroxy acids are obtained with good enantiomeric excess by stereodivergent reduction of these hemiacetals. Reaction with Grignard reagents at ambient temperature furnishes (R) α-alkyl mandelic acids with good stereoselectivity.
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Doi:10.1021/om9807396
(1999)Doi:10.1055/s-1998-2218
(1998)Doi:10.1002/chem.202004300
(2021)Doi:10.1016/S0957-4166(98)00385-1
(1998)Doi:10.1039/a806283h
(1998)Doi:10.1016/S0022-1139(98)00247-4
(1998)