Stereoselective synthesis of dihydroisocoumarin moiety of microbial agent AI-77-B: A Diels-Alder based strategy

Article abstract of DOI:10.1016/S0040-4039(98)01977-7

The dihydroisocoumarin fragment of the gastroprotective natural product AI-77-B has been synthesized in optically active form by using a regiospecific Diels-Alder reaction of 1-methoxy-1,3-cyclohexadiene and an acetylenic ester derivative, prepared stereo