Bioorganic and Medicinal Chemistry Letters p. 3409 - 3414 (1998)
Update date:2022-08-04
Topics:
Plummer, Janet S.
Berryman, Kent A.
Cai, Cuiman
Cody, Wayne L.
Dimaio, John
Doherty, Annette M.
Edmunds, Jeremy J.
He, John X.
Holland, Debra R.
Levesque, Sophie
Kent, Darin R.
Narasimhan, Lakshmi S.
Rubin, J. Ronald
Rapundalo, Stephen T.
Siddiqui, M. Arshad
Susser, Alan J.
St-Denis, Yves
Winocour, Peter D.
The synthesis and antithrombotic activity of a series of nonpeptide bicyclic thrombin inhibitors is described. We have explored the SAR with modifications to the P1 site. The introduction of arginine mimetics at the P1 site led to potent and selective thrombin inhibitors.
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Doi:10.1016/S0960-894X(98)00551-4
(1998)Doi:10.1021/ja983248l
(1999)Doi:10.1002/jccs.199800121
(1998)Doi:10.1021/jm0582423
(2005)Doi:10.1002/(SICI)1521-3765(19981204)4:12<2558::AID-CHEM2558>3.0.CO;2-3
(1998)Doi:10.1016/S0277-5387(98)00277-0
(1998)
