Bioorganic and Medicinal Chemistry Letters p. 3409 - 3414 (1998)
Update date:2022-08-04
Topics:
Plummer, Janet S.
Berryman, Kent A.
Cai, Cuiman
Cody, Wayne L.
Dimaio, John
Doherty, Annette M.
Edmunds, Jeremy J.
He, John X.
Holland, Debra R.
Levesque, Sophie
Kent, Darin R.
Narasimhan, Lakshmi S.
Rubin, J. Ronald
Rapundalo, Stephen T.
Siddiqui, M. Arshad
Susser, Alan J.
St-Denis, Yves
Winocour, Peter D.
The synthesis and antithrombotic activity of a series of nonpeptide bicyclic thrombin inhibitors is described. We have explored the SAR with modifications to the P1 site. The introduction of arginine mimetics at the P1 site led to potent and selective thrombin inhibitors.
View MoreTianjin SPHINX SCIENTIFIC LAB.
Contact:+86-022-66211289
Address:Tianda high-tech Park. No.80,the 4th Avenue
Jinhua City Mingzhu Pharmaceutical Co.,Ltd.
Contact:15857995878 0579-82207761
Address:No.169 Shenze Road, New Area,Jinpan Development Zone, Jinhua
Lishui Nanming Chemical Co., Ltd(expird)
Contact:+86-0578-2134101，2697830
Address:No.19 Tongji Road Shuige Industrial zone
Contact:+33-5-34012600
Address:28 ZA des Pignès
Linyi Shengxin Pharmaceutical R&D Co., Ltd
Contact:+86-18653953873
Address:West First of Yufeng Road, Yishui County
Doi:10.1016/S0960-894X(98)00551-4
(1998)Doi:10.1021/ja983248l
(1999)Doi:10.1002/jccs.199800121
(1998)Doi:10.1021/jm0582423
(2005)Doi:10.1002/(SICI)1521-3765(19981204)4:12<2558::AID-CHEM2558>3.0.CO;2-3
(1998)Doi:10.1016/S0277-5387(98)00277-0
(1998)
