Synthesis and evaluation of paclitaxel C7 derivatives: Solution phase synthesis of combinatorial libraries

DOI: 10.1016/S0960-894X(98)00551-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3181 - 3186 (1998)

Update date:2022-08-04

Topics:

Authors:

Bhat, Laxminarayan

Liu, Yanbin

Victory, Sam F.

Himes, Richard H.

Georg, Gunda I.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00551-4

A novel and efficient two-step, automated solution phase synthesis of a 26-membered combinatorial chemistry library of paclitaxel C7 esters was accomplished using the HP 7686 Solution Phase Synthesizer. Results of combinatorial synthesis, purification, analysis, and biological evaluation are described.

Full text of DOI:10.1016/S0960-894X(98)00551-4

Products guided by the article

Product name:C₆₂H₇₃NO₁₅Si

Cas No:220178-07-4

R&D Labs maybe for 220178-07-4

Shanghai shibo Chemical Co., Ltd

Contact:+86-021-60753516

Address:688 Qiushi Road, Jinshan High-tech Park, Shanghai, China,201512
Zhejiang Haizhou Pharmaceutical Co., Ltd.

website:https://www.haizhoupharma.com/

Contact:+86-576-88221016

Address:No. 19, Donghai 5th Avenue, Yanhai Industrial Zone, Linhai, Zhejiang, China
Hotechem Shanghai Co., Ltd

Contact:13120882795；+86-21-34621078;+86-021-31122318

Address:Suite 2,No.2715 Longwu Road
SuZhou Ascepion Pharmaceuticals, Inc.(expird)

Contact:0512-86881668

Address:Building C,68Xingqing Road,Suzhou,China.
ShanDong XinDa Chemical CO.,LTD(expird)

Contact:086-0311-87580543

Address:No.168, High Technology Development Zone Jinan Shandong China

Relevant to this article

Salicylate exchange in meso-tetraphenylporphyrinato salicylato thallium (III), Tl (tpp) (2-OH-C6H4CO2) and ¹³C NMR investigation of its homolog thiocyanato (meso-tetra-p-tolyl-porphyrinato)thallium (III), Tl (tptp) (SCN)

Doi:10.1016/S0277-5387(98)00277-0
(1998)
A novel, thioacetal based linker for solid-phase synthesis

Doi:10.1016/S0040-4039(98)02580-5
(1999)
Efficient Microwave Method for the Oxidative Coupling of Phenols

Doi:10.1080/00397911.2014.956370
(2015)
2,2-dioxo-1H-thieno[3,4-c][1,2]thiazines. Synthesis and some reactions of a new heterocycle

Doi:10.1002/jhet.5570350639
(1998)
Stereoselective radical cascade approach to benzo[a]quinolizidines

Doi:10.1016/S0040-4039(98)02550-7
(1999)
Asymmetric Synthesis of (-)-Pterocarine and (-)-Galeon via Chiral Phase Transfer-Catalyzed Atropselective Formation of Diarylether Cyclophane Skeleton

Doi:10.1021/acs.orglett.7b00570
(2017)

Article Doi