Synthesis and evaluation of paclitaxel C7 derivatives: Solution phase synthesis of combinatorial libraries

DOI: 10.1016/S0960-894X(98)00551-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3181 - 3186 (1998)

Update date:2022-08-04

Topics:

Authors:

Bhat, Laxminarayan

Liu, Yanbin

Victory, Sam F.

Himes, Richard H.

Georg, Gunda I.

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Article abstract of DOI:10.1016/S0960-894X(98)00551-4

A novel and efficient two-step, automated solution phase synthesis of a 26-membered combinatorial chemistry library of paclitaxel C7 esters was accomplished using the HP 7686 Solution Phase Synthesizer. Results of combinatorial synthesis, purification, analysis, and biological evaluation are described.

Full text of DOI:10.1016/S0960-894X(98)00551-4

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