Use of the Suzuki reaction for the synthesis of aryl-substituted heterocycles as corticotropin-releasing hormone (CRH) antagonists

DOI: 10.1016/S0960-894X(99)00133-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1063 - 1066 (1999)

Update date:2022-08-02

Topics:

Authors:

Cocuzza, Anthony J.

Chidester, Dennis R.

Culp, Steven

Fitzgerald, Lawrence

Gilligan, Paul

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00133-X

The Suzuki reaction has been used to synthesize a variety of aryl- substituted heterocyclic antagonists of the CRH₁ receptor. Examples with several different heterocyclic cores are potent CRH receptor ligands.

Full text of DOI:10.1016/S0960-894X(99)00133-X

Products guided by the article

Product name:4-(2-Bromo-4,6-dimethoxyphenyl)amino-2-methyl-5-nitro-6-(2-(trifluoromethyl)phenyl)pyrimidine

Cas No:219840-93-4

R&D Labs maybe for 219840-93-4

Ningjiang Chemical Factory

website:http://pharmchemlabs.lookchem.com/

Contact:+86-576-88283887

Address:Yantou Chemical Industry Zone,Jiaojiang
Nanjing Chemzam Pharmtech Co., Ltd.

Contact:+86-25-86462165,+86-13915979898

Address:C5-1，6 Maiyue Road，Maigaoqiao，Nanjing，Jiangsu，China
SHENZHEN PENGCHENG REDSTAR INDUSTRY CO.,LTD

Contact:+86-755-82412922

Address:Room 8066, East Block, Square City, Jiabin Road, Luohu District
zhenjiang runjing high purity chemical co ltd

Contact:+86-511-83361155

Address:No.8.haixi road,international chemical park
Hangzhou Yingshanhua Pigment Chemicals Co.,Ltd.

Contact:+86-0150-58101658

Address:Nanyang Economic DevelopmentZong,Xiaoshan,Hangzhou,China

Relevant to this article

1,3-Bis(3-nitrophenyl)triazene

Doi:10.1107/S0108270198010415
(1999)
The stereochemical course of addition of allyltrimethylsilane to protected L-alaninals and L-serinals in the presence of Lewis acids. Total synthesis of cis-(2R,3S)-3-hydroxyproline

Doi:10.1016/S0957-4166(02)00255-0
(2002)
Mono- and disubstituted N,N-dialkylcyclopropylamines from dialkylformamides via ligand-exchanged titanium - Alkene complexes

Doi:10.1002/1521-3765(20020816)8:16<3789::AID-CHEM3789>3.0.CO;2-R
(2002)
Novel benzo-fused lactam scaffolds as factor Xa inhibitors

Doi:10.1016/S0960-894X(99)00417-5
(1999)
Doi:10.1002/hlca.19690520826
(1969)
Oxidation and rearrangement of 5-substituted 5- ethoxycarbonyl[1,2,4]triazolidine-3-thiones

Doi:10.3987/com-98-s(h)35
(1999)

Article Doi