European Journal of Medicinal Chemistry p. 899 - 903 (1998)
Update date:2022-08-03
Topics:
Cecchetti, Violetta
Fravolini, Arnaldo
Sabatini, Stefano
Tabarrini, Oriana
Xin, Tao
A series of dibenzo[1,6]naphthyridindiones, synthesized as modified quinolones, in which the usual carboxylic group was replaced by a heterocyclic amide function, was evaluated for antibacterial activity. None of the target compounds showed any significant antibacterial activity. Semiempirical molecular orbital AM1 calculations allowed us to hypothesize that the lack of activity could depend on amide tautomeric equilibrium.
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