Bioorganic and Medicinal Chemistry Letters p. 33 - 38 (1996)
Update date:2022-08-04
Topics:
Kato, Masayuki
Nishino, Shigetaka
Ohno, Mitsuko
Fukuyama, Shinichi
Kita, Yasuhiro
Hirasaw, Yoshimi
Nakanishi, Isao
Takasugi, Hisashi
Sakane, Kazuo
The synthesis and structure-stability relationships of a series of novel FK409 derivatives are described. The rates of decomposition in aqueous solution (pH 8.0, 30°C) were parallel with those of spontaneous NO release measured by ESR spectroscopy using carboxy-PTIO. The compounds can cover a wide range of NO releasing rates by appropriate modification of the molecule.
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