New reagents for controlled release of nitric oxide. Structure-stability relationships

DOI: 10.1016/0960-894X(95)00547-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 33 - 38 (1996)

Update date:2022-08-04

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Authors:

Kato, Masayuki

Nishino, Shigetaka

Ohno, Mitsuko

Fukuyama, Shinichi

Kita, Yasuhiro

Hirasaw, Yoshimi

Nakanishi, Isao

Takasugi, Hisashi

Sakane, Kazuo

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Article abstract of DOI:10.1016/0960-894X(95)00547-7

The synthesis and structure-stability relationships of a series of novel FK409 derivatives are described. The rates of decomposition in aqueous solution (pH 8.0, 30°C) were parallel with those of spontaneous NO release measured by ESR spectroscopy using carboxy-PTIO. The compounds can cover a wide range of NO releasing rates by appropriate modification of the molecule.

Full text of DOI:10.1016/0960-894X(95)00547-7

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