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New reagents for controlled release of nitric oxide. Structure-stability relationships

DOI: 10.1016/0960-894X(95)00547-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 33 - 38 (1996)

Update date:2022-08-04

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Authors:

Kato, MasayukiKato, Masayuki

Nishino, ShigetakaNishino, Shigetaka

Ohno, MitsukoOhno, Mitsuko

Fukuyama, ShinichiFukuyama, Shinichi

Kita, YasuhiroKita, Yasuhiro

Hirasaw, YoshimiHirasaw, Yoshimi

Nakanishi, IsaoNakanishi, Isao

Takasugi, HisashiTakasugi, Hisashi

Sakane, KazuoSakane, Kazuo

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Article abstract of DOI:10.1016/0960-894X(95)00547-7

The synthesis and structure-stability relationships of a series of novel FK409 derivatives are described. The rates of decomposition in aqueous solution (pH 8.0, 30°C) were parallel with those of spontaneous NO release measured by ESR spectroscopy using carboxy-PTIO. The compounds can cover a wide range of NO releasing rates by appropriate modification of the molecule.

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Full text of DOI:10.1016/0960-894X(95)00547-7

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