Synthesis of cationic lipids from 1,2,4-butanetriol

Article abstract of DOI:10.1016/S0040-4039(98)02381-8

Starting from 1,2,4-butanetriol, a series of quaternary ammonium lipids with diether, ether/ester, and diester bonds as linkage between the hydrocarbon chains and butane backbone were synthesized for gene delivery.