Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: Modifications of essential pyrrolidinone ring substituents

DOI: 10.1016/S0968-0896(03)00271-2

Source and publish data:

Bioorganic and Medicinal Chemistry p. 2739 - 2749 (2003)

Update date:2022-08-05

Topics:

Authors:

Brouillette, Wayne J.

Bajpai, Saroj N.

Ali, Shoukath M.

Velu, Sadanandan E.

Atigadda, Venkatram R.

Lommer, Barbara S.

Finley, James B.

Luo, Ming

Air, Gillian M.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0968-0896(03)00271-2

We recently reported the first benzoic acid, 1-[4-carboxy-2-(3-pentylamino)phenyl]-5,5-bis(hydroxymethyl)pyrrolidin-2-one (8), that is a potent inhibitor of avian influenza A neuraminidase (N9) and, unlike other reported potent neuraminidase inhibitors, d

Full text of DOI:10.1016/S0968-0896(03)00271-2

Products guided by the article

Product name:Benzoic acid, 3-nitro-4-(2-oxo-8-phenyl-7,9-dioxa-1-azaspiro[4.5]dec-1-yl)-, methyl ester

Cas No:221382-26-9

R&D Labs maybe for 221382-26-9

Chemsigma International Co.,Ltd.

website:http://www.chemsigma.com

Contact:86-025-58748998

Address:Rm.705, 15th Building,Rd.Xinke II
HANGZHOU TOYOND BIOTECH CO., LTD

Contact:+86-571-86965177

Address:No. 189, Fengqi East Road, Hangzhou, China
Zhejiang Linhai Xinhua Chemicals Factory

Contact:0086-13661858911

Address:Xunqiao Development Zone, Linhai, Zhejiang, China
Reliable Pharma Technology (Shanghai) Co., Ltd.

Contact:0086-21-67676847-8008

Address:Lane 1500, No.68, Xinfei Road, Songjiang District, Shanghai, 201611, P.R.China.
Laohekou Jinghong Chemical Co.,Ltd

Contact:+86-0710-3702747

Address:163.East，Huagong Road，Laohekou

Relevant to this article

Development of a donor-acceptor concept for enzymatic cross-coupling reactions of aldehydes: The first asymmetric cross-benzoin condensation

Doi:10.1021/ja0271476
(2002)
Identification of a selective small molecule inhibitor of breast cancer stem cells

Doi:10.1016/j.bmcl.2012.01.035
(2012)
The regioselective bromine-lithium exchange reaction of alkoxymethyldibromobenzene: A new strategy for the synthesis of tofogliflozin as a SGLT2 inhibitor for the treatment of diabetes

Doi:10.1016/j.tet.2016.12.028
(2017)
Lewis acid promoted hetero [2 + 2] cycloaddition reactions of aldehydes with 10-propynyl-9(10h)-acridone. A highly stereoselective synthesis of acrylic acid derivatives and 1,3-dienes using an electron deficient variant of ynamine

Doi:10.1021/ol990211c
(1999)
Concise Xanthine Synthesis through a Double-Amidination Reaction of a 6-Chlorouracil with Amidines using Base-Metal Catalysis

Doi:10.1002/cssc.201601483
(2017)
Doi:10.1002/jhet.5570390113
(1889)

Article Doi