Synthesis and Absolute Configuration of a Novel Aminoglycoglycerolipid, Species-Specific Major Immunodeterminant of Mycoplasma fermentans

Article abstract of DOI:10.1016/S0040-4039(99)00191-4

In order to determine the absolute configuration of a novel aminoglycoglycerolipid isolated from Mycoplasma fermentans, the possible two diastereomers were stereoselectively synthesized by using (S)- and (R)-glycidols as the key building block. Their 1H-1H-cosy spectra compared with those of the natural product allowed us to determine the absolute configuration of the glycolipid. - Keywords: amino-alcohols; glycolipids; immunodeficiency; phospholipids; phosphoramidites