Synthesis and biological activities of [N-MeLeu5]- and [N-MePhe5]- didemnin B

DOI: 10.1016/S0040-4020(98)01042-4

Source and publish data:

Tetrahedron p. 313 - 334 (1999)

Update date:2022-08-04

Topics:

Authors:

Pfizenmayer, Amy J.

Ramanjulu, Joshi M.

Vera, Matthew D.

Ding, Xiaobin

Xiao, Dong

Chen, Wei-Chuan

Joullie, Madeleine M.

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Article abstract of DOI:10.1016/S0040-4020(98)01042-4

Based on information from X-ray, NMR, and SAR data, the N,O-diMeTyr⁵ unit of didemnin B was believed to be important for biological activity. To determine the importance of aromaticity and the role of the methoxy group in this unit, two analogs

Full text of DOI:10.1016/S0040-4020(98)01042-4

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