Synthesis of an inositol-containing trisaccharide related to insulin signal transduction

DOI: 10.1016/S0040-4039(98)02530-1

Source and publish data:

Tetrahedron Letters p. 667 - 670 (1999)

Update date:2022-08-04

Topics:

Authors:

Jaworek, Christine H.

Calias, Pericles

Iacobucci, Sarah

D'Alarcao, Marc

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Article abstract of DOI:10.1016/S0040-4039(98)02530-1

A synthesis of D-mannosyl-(α1-4)-D-glucosaminyl-(α1-6)-D-myo-inositol- 1:2-cyclic phosphate (1) from D-xylose, D-mannose, and D-glucal is reported. Compound 1 constitutes the terminal structure of the PI-PLC-released VSG membrane anchor of Trypanosomes and is structurally related to the inositol phosphate glycan implicated as an insulin second messenger in higher organisms.

Full text of DOI:10.1016/S0040-4039(98)02530-1

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