Bioorganic and medicinal chemistry letters p. 69 - 74 (1999)
Update date:2022-07-30
Topics:
Shih, Chuan
Gossett, Lynn S.
Gruber, Joseph M.
Grossman, C. Sue
Andis, Sherri L.
et al.
Structure modification of the β-alanine region (fragment C) of the potent antimitotic agent cryptophycin was investigated. This includes: (1) introduction of substituents at the previously unsubstituted C7 position of the macrolide ring and (2) replacement of the (2R)-3-amino-2-methyl-propanoic acid (β-alanine) with various (l)-amino acids to give the corresponding 15-membered unnatural cryptophycin analogs.
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