Moenomycin A: The role of the methyl group in the moenuronamide unit and a general discussion of structure-activity relationships

DOI: 10.1016/S0040-4020(98)01063-1

Source and publish data:

Tetrahedron p. 699 - 722 (1999)

Update date:2022-08-02

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Authors:

El-Abadla, Naser

Lampilas, Maxime

Hennig, Lothar

Findeisen, Matthias

Welzel, Peter

Mueller, Dietrich

Markus, Astrid

Van Heijenoort, Jean

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Article abstract of DOI:10.1016/S0040-4020(98)01063-1

Two disaccharide analogues lb and 17a of moenomycin A have been synthesized and their antibiotic and transglycosylase-inhibiting properties have been determined. The results permit for the first time to arrive at a general view of the structural requirements in this class of compounds necessary to elicit antibiotic activity.

Full text of DOI:10.1016/S0040-4020(98)01063-1

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