Bioorganic and medicinal chemistry letters p. 2479 - 2482 (2002)
Update date:2022-08-04
Topics:
Sidduri, Achyutharao
Tilley, Jefferson W
Lou, Jian Ping
Chen
Kaplan, Gerry
Mennona, Frank
Campbell, Robert
Guthrie, Robert
Huang, Tai-Nan
Rowan, Karen
Schwinge, Virginia
Renzetti, Louis M
A series of N-benzoyl-4-[(2,6-dichlorobenzoyl)amino]-L-phenylalanine derivatives was prepared in order to optimize the substitution on the N-benzoyl moiety for VCAM/VLA-4 antagonist activity. Disubstitution in the 2- and 6-positions is favored and a range
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(2021)
