Addition of chiral β-hydroxy (protected) enol silanes to benzaldehyde dimethyl acetal: Access to polypropionate five-carbon stereosequences

DOI: 10.1016/S0040-4039(98)02584-2

Source and publish data:

Tetrahedron Letters p. 1123 - 1124 (1999)

Update date:2022-08-05

Topics:

Authors:

Lefranc, Herve

Szymoniak, Jan

Delas, Christophe

Moise, Claude

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Article abstract of DOI:10.1016/S0040-4039(98)02584-2

The title enol silanes react with benzaldehyde dimethyl acetal to give dihydroxy (protected) ketones with good to excellent de and enantiocontrol. Further DIBALH reduction affords stereoselectively (de=95%) polypropionate chirons.

Full text of DOI:10.1016/S0040-4039(98)02584-2

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