Pyranosyl-RNA supramolecules containing non-hydrogen bonding base pairs

Article abstract of DOI:10.1055/s-1999-3112

Synthesis and properties of a new pyranosyl-RNA nucleoside using tryptamine as nucleo-base is reported. Incorporation of this unit into oligomers using standard phosphoamidite chemistry yielded self-complementary and non-selfcomplementary oligonucleotide pairs. Thermal melting experiments of these examples showed the sequence dependent stabilising characteristics of the incorporated base in the symmetric pairing constitution with a standard T(m) near that of a similar A-T-pair as well as pairing selectivity with respect to non-symmetric pairing tolerating thymine but destabilizing if confronted to an adenine as complementary base in the antiparallel strand.