The synthesis and biological activity of a series of 2,4- diaminopyrido[2,3-d]pyrimidine based antifolates as antineoplastic and antiarthritic agents

Article abstract of DOI:10.1016/S0960-894X(98)00683-0

A new series of 2,4-diaminopyrido[2,3-d]pyrimidine based antifolates 1- 3 were synthesized through an efficient conversion of 2-pivaloyl-4-oxo-6- ethynylpyrido[2,3-d]pyrimidine 5 to the corresponding 4-amino analog 7 via the activated 1,2,4-triazole inter