Synthesis of 6-substituted-3-hydroxy-4(1H)-pyridinones: Oxidation- Michael addition of 3-hydroxy-4(1H)-pyridinones

DOI: 10.1016/S0040-4020(99)00008-3

Source and publish data:

Tetrahedron p. 2237 - 2244 (1999)

Update date:2022-08-03

Topics:

Authors:

Li, Miao-Sheng

Gu, Lian-Quan

Huang, Zhi-Shu

Xiao, Shao-Hua

Ma, Lin Ma, Lin

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Article abstract of DOI:10.1016/S0040-4020(99)00008-3

2-Alkyl-3-hydroxy-4(1H)-pyridinones can be oxidized by silver(I) oxide in alcoholic solution to give 2-alkoxy-2-alkyl-1,2-dihydro-pyridine-3,4- diones, which can subsequently undergo a Michael addition with nucleophiles to give 6-substituted-2-alkyl-3-hyd

Full text of DOI:10.1016/S0040-4020(99)00008-3

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Product name:4(1H)-Pyridinone, 2-ethyl-3-hydroxy-6-[(2-hydroxyethyl)thio]- (9CI)

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