Synthesis of 6-substituted-3-hydroxy-4(1H)-pyridinones: Oxidation- Michael addition of 3-hydroxy-4(1H)-pyridinones

Article abstract of DOI:10.1016/S0040-4020(99)00008-3

2-Alkyl-3-hydroxy-4(1H)-pyridinones can be oxidized by silver(I) oxide in alcoholic solution to give 2-alkoxy-2-alkyl-1,2-dihydro-pyridine-3,4- diones, which can subsequently undergo a Michael addition with nucleophiles to give 6-substituted-2-alkyl-3-hyd