Simple one-pot synthesis of a 2'-tritium labeled C-deoxynucleoside

DOI: 10.1016/S0960-894X(99)00068-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 723 - 726 (1999)

Update date:2022-07-29

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Authors:

Lutz, Stefan

Benner, Steven A.

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Article abstract of DOI:10.1016/S0960-894X(99)00068-2

The deoxygenation and 2'-labeling of a C-ribonucleoside by reductive elimination with tri-n-butyltin hydride[³H] in a one-pot reaction is described. The approach is a safe, simple, efficient, and general method for 2'-labeling of nucleosides.

Full text of DOI:10.1016/S0960-894X(99)00068-2

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