Chemical and Pharmaceutical Bulletin p. 156 - 164 (1999)
Update date:2022-07-29
Topics:
Wahid, Farid
Monneret, Claude
Dauzonne, Daniel
A series of about fifty novel 5-arylfuro[2,3-d]pyrimidine derivatives were synthesized as potential inhibitors of dihydrofolate reductase (DHFR) arising from different species. Weak enzyme inhibition was observed for most of the compounds, with only a few reaching IC50 values less than 30 μM. With regards to antibacterial and antimalarial potency, only seven compounds showed a modest in vitro activity against some bacteria strains and only three products proved significantly active against P. falciparum.
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