Bioorganic and Medicinal Chemistry Letters p. 1133 - 1138 (1998)
Update date:2022-08-04
Topics:
Ali, Syed M.
Tedford, Clark E.
Gregory, Rosilyn
Yates, Stephen L.
Phillips, James G.
New histamine H3 receptor antagonists were developed using an acetylene moiety as a replacement for the amide-oxime functionality of verongamine 5. Optimization of receptor binding was performed by following aliphatic Topliss tree guidelines. These new H3 ligands demonstrate excellent blood-brain barrier penetration.
View MoreJiangxi Hito Chemical Co., Ltd.
Contact:+86-792-3170318
Address:No. 6, Tianhong Ave., Xinghuo Industry Park, Yongxiu, Jiujiang, Jiangxi, China
Nanjing Fubang Chemical Co.,Ltd
Contact:+86-25-83179199
Address:5F,Tianzheng international plaza,No399 Zhongyang Road ,Nanjing China
Contact:21-7631221 15884421033
Address:326 Science and technology,Shanghai,China
Wuhan Chemwish Technology Co., Ltd
website:http://www.chemwish.com/
Contact:+86-27-67849912
Address:Room 1311, Unit 2, Block1, Innovation Road East Lake High-tech Development Zone Wuhan, Hubei，P.R. China
Dalian Join King Biochemical Tech. Co., Ltd.
Contact:0411 39216206
Address:814 First State Blvd
Doi:10.1021/jo981487l
(1999)Doi:10.1021/jm0301787
(2003)Doi:10.1016/j.bmc.2016.11.037
(2017)Doi:10.1007/BF00515577
(1991)Doi:10.1021/acs.jmedchem.8b00613
(2018)Doi:10.1021/ja00837a028
(1975)
