Bioorganic and Medicinal Chemistry Letters p. 1133 - 1138 (1998)
Update date:2022-08-04
Topics:
Ali, Syed M.
Tedford, Clark E.
Gregory, Rosilyn
Yates, Stephen L.
Phillips, James G.
New histamine H3 receptor antagonists were developed using an acetylene moiety as a replacement for the amide-oxime functionality of verongamine 5. Optimization of receptor binding was performed by following aliphatic Topliss tree guidelines. These new H3 ligands demonstrate excellent blood-brain barrier penetration.
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