Substituted furans as inhibitors of the PDE4 enzyme

DOI: 10.1016/S0960-894X(98)00742-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 323 - 326 (1999)

Update date:2022-08-05

Topics:

Authors:

Perrier, Helene

Bayly, Christopher

Laliberte, France

Huang, Zheng

Rasori, Roberta

Robichaud, Annette

Girard, Yves

Macdonald, Dwight

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00742-2

The synthesis and in vitro activity of a series of substituted furans as a novel structural class of PDE4 inhibitors is described. Comparison of emetic threshold with known PDE4 inhibitors is presented.

Full text of DOI:10.1016/S0960-894X(98)00742-2

Products guided by the article

Product name:[2-(3-cyclopentyloxy-4-methoxy-phenyl)-5-pyridin-2-yl-furan-3-yl]-phenyl-methanol

Cas No:222962-07-4

R&D Labs maybe for 222962-07-4

Chengdu Cogon Bio-tech Co., Ltd.

Contact:86-28-85171192

Address:NO.52.YongFeng Rd. Chengdu,610041,P.R.China.
Shanghai birch chemical technology co.,ltd

Contact:+86-21-54096810

Address:No.2588,Jungong Road,Shanghai,China
Zhejiang Rongkai Chemical Technology Co.,Ltd.

Contact:+86-578-8185786

Address:Shangjiang Industrial Zone,Suichang
Shao Xing Empire Import&Export CO.,ltd

Contact:86-575-82127757

Address:11#, Weiwu Road, Shangyu Industrial Park, Hangzhou Bay, Hangzhou, Zhejiang Province, China
Shifang Taifeng New Flame Retardant Co., Ltd

Contact:02884721008

Address:tingjiang industrial park, hefeng town

Relevant to this article

Design, synthesis, and structure-activity relationships of potent GPIIb/IIIa antagonists: Discovery of FK419

Doi:10.1016/j.bmc.2005.03.056
(2005)
Synthesis and photoreactivity of a 2-pivaloylcyclohex-2-enone

Doi:10.1039/a808422j
(1999)
Self-organizable vesicular columns assembled from polymers dendronized with semifluorinated janus dendrimers act as reverse thermal actuators

Doi:10.1021/ja2118267
(2012)
Structure-Activity Relationships of 6- and 8-Gingerol Analogs as Anti-Biofilm Agents

Doi:10.1021/acs.jmedchem.7b01426
(2017)
Selective Oxidation of Activated Alcohols by Supported Gold Nanoparticles under an Atmospheric Pressure of O₂: Batch and Continuous-Flow Studies

Doi:10.1002/cctc.201700179
(2017)
Synthesis of pseudoaromatic expanded porphyrin analogues

Doi:10.1016/S0040-4039(99)00044-1
(1999)

Article Doi