Substituted furans as inhibitors of the PDE4 enzyme

DOI: 10.1016/S0960-894X(98)00742-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 323 - 326 (1999)

Update date:2022-08-05

Topics:

Authors:

Perrier, Helene

Bayly, Christopher

Laliberte, France

Huang, Zheng

Rasori, Roberta

Robichaud, Annette

Girard, Yves

Macdonald, Dwight

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Article abstract of DOI:10.1016/S0960-894X(98)00742-2

The synthesis and in vitro activity of a series of substituted furans as a novel structural class of PDE4 inhibitors is described. Comparison of emetic threshold with known PDE4 inhibitors is presented.

Full text of DOI:10.1016/S0960-894X(98)00742-2

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Product name:[2-(3-cyclopentyloxy-4-methoxy-phenyl)-5-pyridin-2-yl-furan-3-yl]-phenyl-methanol

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