The structural requirements for inhibition of proteasome function by the lactacystin-derived β-lactone and synthetic analogs

DOI: 10.1016/S0040-4020(98)01142-9

Source and publish data:

Tetrahedron p. 3305 - 3316 (1999)

Update date:2022-07-29

Topics:

Authors:

Corey Corey

Li, Wei-Dong Z.

Nagamitsu, Tohru

Fenteany, Gabriel

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4020(98)01142-9

The synthesis of analogs of the lactacystin-derived β-lactone (2) in which the substituents at C(5), C(7) and C(9) were systematically varied has led to a well defined structure-activity correlation for the highly selective inhibition of the mammalian 20 S proteasome.

Full text of DOI:10.1016/S0040-4020(98)01142-9

Products guided by the article

Product name:(2R,3S,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-((S)-1-hydroxy-allyl)-1-(4-methoxy-benzyl)-4-methyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester

Cas No:223246-02-4

R&D Labs maybe for 223246-02-4

Changzhou Sunlight Pharmaceutical Co., Ltd.

Contact:+86-519-83131668;83139028;83138042;83137041

Address:JiuliStreet, Benniu Town Changzhou City, Jiangsu Province
Valiant Fine Chemicals Co., Ltd.

Contact:+86 535 6101878/6374484

Address:11 Wuzhishan Rd.,YTETDZ,Yantai,264006,Shandong,China
Jinan Jianfeng Chemical Co., Ltd

Contact:0086-531-88110457

Address:sales01(-a-t-)pharmachemm{dot}c+o+m
Zhengzhou Yuanli Biological Technology Co., Ltd.

Contact:+86-371-67897870/67897895

Address:No. 38, Qingyang Street, Zhengzhou, Henan, China
Yurui(Shanghai)Chemical Co.,Ltd

Contact:0086 21-50456736

Address:No.3188 Xiupu Road,Shanghai

Relevant to this article

Chemistry of fluorinated enamines. Novel reaction of trifluoromethylated enamine with Grignard reagents

Doi:10.1016/S0040-4039(99)00399-8
(1999)
A NEW, CONVENIENT AND EFFICIENT GENERAL PROCEDURE FOR THE CONVERSION OF ALCOHOLS INTO THEIR DIBENZYL PHOSPHOROTRIESTERS USING N,N-DIETHYL DIBENZYL PHOSPHORAMIDITE

Doi:10.1016/S0040-4039(00)95660-0
(1987)
β-nitro-α-amino acids as latent α,β-dehydro-α-amino acid residues in peptides

Doi:10.1016/S0040-4039(99)00839-4
(1999)
A new class of potent RAR antagonists: Dihydroanthracenyl, benzochromenyl and benzothiochromenyl retinoids

Doi:10.1016/S0960-894X(99)00077-3
(1999)
Formal synthesis of D-myo-inositol 1,4,5-tris(dihydrogen phosphate): Cyclization by an unusual ene reaction and use of the Bu₂SnCl₂/Bu₂SnH₂ reagent for generating an equatorial alcohol

Doi:10.1021/jo990086i
(1999)
Doi:10.1246/bcsj.42.185
(1969)

Article Doi