The structural requirements for inhibition of proteasome function by the lactacystin-derived β-lactone and synthetic analogs

DOI: 10.1016/S0040-4020(98)01142-9

Source and publish data:

Tetrahedron p. 3305 - 3316 (1999)

Update date:2022-07-29

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Authors:

Corey Corey

Li, Wei-Dong Z.

Nagamitsu, Tohru

Fenteany, Gabriel

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Article abstract of DOI:10.1016/S0040-4020(98)01142-9

The synthesis of analogs of the lactacystin-derived β-lactone (2) in which the substituents at C(5), C(7) and C(9) were systematically varied has led to a well defined structure-activity correlation for the highly selective inhibition of the mammalian 20 S proteasome.

Full text of DOI:10.1016/S0040-4020(98)01142-9

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