Bioorganic and Medicinal Chemistry Letters p. 563 - 568 (1999)
Update date:2022-08-03
Topics:
Hu, Ming-Kuan
Yang, Fu-Chu
Chou, Chi-Cheun
Yen, Mao-Hsiung
Leualacin (1), a cyclic depsi-pentapeptide, and its backbone/amidemodified analogs 2-4 were synthesized. Amide analogue 3 exhibited stronger vasodilatory effects. It also strongly inhibited collagen- and arachidonic acid (AA)induced platelet aggregations with IC50s of 0.6 μM and 2.0 μM, respectively.
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Doi:10.1016/S0040-4020(99)00068-X
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(1999)
