Conclusion
In this study a new dinuclear zinc() complex was reported as
the first dizinc functional model of aminopeptidase. Although
the aminopeptidase activity of the complex was far from satis-
factory, it was useful as a first step of functional modelling of
dinuclear zinc aminopeptidases. As a second step it is necessary
to design a dinucleating ligand which is also good for substrate
incorporation for better aminopeptidase activity.
Acknowledgements
We are grateful to Mr Hideaki Kudo for measuring H NMR,
1
and Mr Takashi Igarashi, Mr Osamu Ito and Miss Tomoko
Koide of Institute for Life Support Technology, Yamagata
Technopolis Foundation for their help in FAB mass spectro-
metric measurements.
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