Bioorganic and Medicinal Chemistry Letters p. 195 - 200 (1999)
Update date:2022-07-31
Topics:
Fink, Cynthia A.
Carlson, J. Eric
Boehm, Charles
McTaggart, Patricia
Qiao, Ying
Doughty, John
Ganu, Vishwas
Melton, Richard
Goldberg, Ronald
A series of thiol containing derivatives was prepared. Several of these compounds were found to inhibit matrix metalloproteinases 1, 3, and 9 with selectivity towards 3 and 9. Compounds 15, 20 and 22 were administered to rats orally at 75 μmol/kg. Drug levels of compounds 20 and 22 in the plasma were found to exceed the IC50 values for MMP 3 and 9 four hours after administration.
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