Design and synthesis of thiol containing inhibitors of matrix metalloproteinases

DOI: 10.1016/S0960-894X(98)00716-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 195 - 200 (1999)

Update date:2022-07-31

Topics:

Authors:

Fink, Cynthia A.

Carlson, J. Eric

Boehm, Charles

McTaggart, Patricia

Qiao, Ying

Doughty, John

Ganu, Vishwas

Melton, Richard

Goldberg, Ronald

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00716-1

A series of thiol containing derivatives was prepared. Several of these compounds were found to inhibit matrix metalloproteinases 1, 3, and 9 with selectivity towards 3 and 9. Compounds 15, 20 and 22 were administered to rats orally at 75 μmol/kg. Drug levels of compounds 20 and 22 in the plasma were found to exceed the IC₅₀ values for MMP 3 and 9 four hours after administration.

Full text of DOI:10.1016/S0960-894X(98)00716-1

Products guided by the article

Product name:1-Hydroxymethyl-4-propyl-cyclohexanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

Cas No:223677-12-1

R&D Labs maybe for 223677-12-1

Jiangxi Hito Chemical Co., Ltd.

Contact:+86-792-3170318

Address:No. 6, Tianhong Ave., Xinghuo Industry Park, Yongxiu, Jiujiang, Jiangxi, China
guide(suzhou) fine materials co. ltd

Contact:0512-80972173

Address:21st Building, No.369 Lushan Rd, New District Suzhou China 215129
WUHAN WELLSONG INT'L CO.,LTD

Contact:+86-27-85733560

Address:NO.308,QINGNIAN RD.,WUHAN,CHINA
HANWAYS CHEMPHARM CO.,LIMITED

website:http://www.hanwayschem.com

Contact:+86-18502787239(whatsapp)-

Address:18-1-802, Green Garden, Jianghan District, Wuhan 430023, China
HANGZHOU ICH BIOFARM CO.,LTD

Contact:+86-571-28186845

Address:Room 1224,Eastcom Mansion,398 Wensan Road,Hangzhou,310013 China

Relevant to this article

Reaction of red phosphorus (P _n) with alkanethiolate anions

Doi:10.1134/S0012500809070052
(2009)
Synthesis of 1-arylamino-5-alkoxycarbonyl-1H-tetrazoles

Doi:10.1080/00397919208021307
(1992)
A Study on the Reducing Abilities of Tris(alkylthio)silanes

Doi:10.1021/jo00034a042
(1992)
5-Substituted 2-amino-4, 6-dihydroxypyrimidines and 2-amino-4, 6-dichloropyrimidines: Synthesis and inhibitory effects on immune-activated nitric oxide production

Doi:10.1007/s00044-014-1018-9
(2014)
The role of organic linkers in directing DNA self-assembly and significantly stabilizing DNA duplexes

Doi:10.1021/ja3033197
(2012)
Sonogashira reactions of 2,3,4,5-tetrabromofuran: Synthesis of 2,3,4,5-tetraalkynylfurans, 2,3,5-trialkynylfurans and 2,5-dialkynylfurans

Doi:10.1055/s-0031-1291007
(2012)

Article Doi