Design and synthesis of thiol containing inhibitors of matrix metalloproteinases

DOI: 10.1016/S0960-894X(98)00716-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 195 - 200 (1999)

Update date:2022-07-31

Topics:

Authors:

Fink, Cynthia A.

Carlson, J. Eric

Boehm, Charles

McTaggart, Patricia

Qiao, Ying

Doughty, John

Ganu, Vishwas

Melton, Richard

Goldberg, Ronald

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Article abstract of DOI:10.1016/S0960-894X(98)00716-1

A series of thiol containing derivatives was prepared. Several of these compounds were found to inhibit matrix metalloproteinases 1, 3, and 9 with selectivity towards 3 and 9. Compounds 15, 20 and 22 were administered to rats orally at 75 μmol/kg. Drug levels of compounds 20 and 22 in the plasma were found to exceed the IC₅₀ values for MMP 3 and 9 four hours after administration.

Full text of DOI:10.1016/S0960-894X(98)00716-1

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