Bioorganic and Medicinal Chemistry Letters p. 1015 - 1018 (2003)
Update date:2022-08-03
Topics: Inhibitors
Burdick, Daniel J.
Paris, Ken
Weese, Kenneth
Stanley, Mark
Beresini, Maureen
Clark, Kevin
McDowell, Robert S.
Marsters Jr., James C.
Gadek, Thomas R.
The association of ICAM-1 with LFA-1 plays a critical role in several autoimmune diseases. N-2-Bromobenzoyl L-tryptophan, compound 1, was identified as an inhibitor to the formation of the LFA-1/ICAM complex. The SAR of the amino acid indicates that the carboxylic acid is required for inhibition and that L-histidine is the most favored amino acid.
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