
Tetrahedron p. 3355 - 3364 (1999)
Update date:2022-07-30
Topics:
Draper, Richard W.
Bin, Hu
McPhail, Andrew T.
Puar, Mohindar S.
Vater, Eugene J.
Weber, Lois
An efficient two stage synthesis of the steroid anti-inflammatory agent mometasone 17-furoate (Sch 32088) 4 from 17α,21-dihydroxy-16α-methyl- 9β,11β-oxidopregna-1,4-diene-3,20-dione 6 is described and the structures of unusual δ-hydroxy-γ-sultone byproducts of 4-dimethylaminopyridine catalyzed methanesulfonylation of 21-hydroxy-20-ketosteroids are deduced.
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Doi:10.1021/ja00747a019
(1971)Doi:10.1002/ardp.19943270812
(1994)Doi:10.1021/np980418z
(1999)Doi:10.1016/S0040-4020(99)00091-5
(1999)Doi:10.1039/c6tc00358c
(2016)Doi:10.1021/jo981620+
(1999)