Unusual hydroxy-γ-sultone byproducts of steroid 21- methanesulfonylation. An efficient synthesis of mometasone 17-furoate (Sch 32088)

DOI: 10.1016/S0040-4020(98)01146-6

Source and publish data:

Tetrahedron p. 3355 - 3364 (1999)

Update date:2022-07-30

Topics:

Authors:

Draper, Richard W.

Bin, Hu Bin, Hu

McPhail, Andrew T.

Puar, Mohindar S.

Vater, Eugene J.

Weber, Lois

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Article abstract of DOI:10.1016/S0040-4020(98)01146-6

An efficient two stage synthesis of the steroid anti-inflammatory agent mometasone 17-furoate (Sch 32088) 4 from 17α,21-dihydroxy-16α-methyl- 9β,11β-oxidopregna-1,4-diene-3,20-dione 6 is described and the structures of unusual δ-hydroxy-γ-sultone byproducts of 4-dimethylaminopyridine catalyzed methanesulfonylation of 21-hydroxy-20-ketosteroids are deduced.

Full text of DOI:10.1016/S0040-4020(98)01146-6

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