Bioorganic and Medicinal Chemistry Letters p. 463 - 468 (1999)
Update date:2022-08-05
Topics:
Dziadulewicz, Edward K.
Brown, Michael C.
Dunstan, Andrew R.
Lee, Wai
Said, Najeeb B.
Garratt, Peter J.
The Bradykinin B2 receptor antagonist HOE 140 (D-Arg-Arg-Pro-Hyp-Gly- Thi-Ser-D-Tic-Oic-Arg) has been used as a template for the de novo design and synthesis of a small number of non-peptide lead compounds based on the 1,4- benzodiazepin-2-one framework. Two of the compounds have been found to exhibit moderate K(i) values of 8.9 and 9.2 μM at the human Bradykinin B2 receptor.
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