Heterocycles p. 677 - 680 (1999)
Update date:2022-07-31
Topics:
Jew, Sang-Sup
Cha, Kyung-Hoi
Kang, Sang-Deog
Woo, Yun-Hee
Kim, Hyung-Ook
Park, Hyeung-Geun
Asymmetric bromolactamization using (S)-(-)-N-methoxy-2-pyrrolidine carboxamide (4) as a chiral auxiliary was performed successfully. The seven membered bromolactam obtained by asymmetric bromolactamization was converted to enantiomerically pure 3(S)-amino-2(R)-methylbutanoic acid (10).
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