Enantioselective synthesis of β-amino acid via asymmetric bromolactamization

Article abstract of DOI:10.3987/COM-98-S(H)109

Asymmetric bromolactamization using (S)-(-)-N-methoxy-2-pyrrolidine carboxamide (4) as a chiral auxiliary was performed successfully. The seven membered bromolactam obtained by asymmetric bromolactamization was converted to enantiomerically pure 3(S)-amino-2(R)-methylbutanoic acid (10).