Bioorganic and Medicinal Chemistry Letters p. 1283 - 1288 (1997)
Update date:2022-07-31
Topics:
Von der Saal, Wolfgang
Kucznierz, Ralf
Leinert, Herbert
Engh, Richard A.
During screening for novel thromin inhibitors it was discovered that the 4-aminopyridine derivative 1 inhibits human α-thrombin competitively and selectively. The 4-aminopyridine moiety itself is most likely the major determinant of the selectivity due to
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