Tetrahedron p. 4489 - 4500 (1999)
Update date:2022-07-30
Topics:
Davis, Benjamin G.
Brandstetter, Tilmann W.
Hackett, Lucy
Winchester, Bryan G.
Nash, Robert J.
Watson, Alison A.
Griffiths, Rhodri C.
Smith, Colin
Fleet, George W. J.
The synthesis of tetrazoles derived from D-manno and D- rhamnopyranose from L-gulonolactone and of L-rhamnopyranose from D-gulonolactone is described. These and other materials are assessed as inhibitors of glycosidases. The [4.3.0] tetrazoles of D-manno- and D-rhamnopyranose are inhibitors of human liver α-mannosidase. In contrast the D-furanose analogues show no inhibitory activity whilst the [3.3.0] L-rhamno furanotetrazole is a potent rhamnosidase inhibitor, a potential inhibitor of mycobacterial cell wall biosynthesis and as such may provide a strategy for the treatment of tuberculosis.
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Doi:10.1021/jo00838a027
(1969)Doi:10.1107/S0108270101005790
(2001)Doi:10.1021/jm980637h
(1999)Doi:10.1016/S0277-5387(98)00426-4
(1999)Doi:10.1021/ol0612962
(2006)Doi:10.1021/acs.orglett.0c00787
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