Selective and efficient synthesis of di-, tri- and tetrasubstituted 1,10-phenanthrolines

Article abstract of DOI:10.1016/S0040-4039(99)00501-8

A general synthetic procedure for the preparation of multisubstituted phenanthrolines is presented. Bromination of 1,10-phenanthroline at the 3 and 8 positions, followed by Suzuki coupling reaction subsequent methylation afford the di-, tri and tetra- substituted phenanthrolines in good yields. These phenanthroline derivatives are useful building blocks in the construction of highly sophisticated molecular architectures.