Bioorganic and Medicinal Chemistry Letters p. 597 - 601 (2007)
Update date:2022-08-02
Topics:
Chang, Linda L.
Truong, Quang
Doss, George A.
MacCoss, Malcolm
Lyons, Kathryn
McCauley, Ermengilda
Mumford, Richard
Forrest, Gail
Vincent, Stella
Schmidt, John A.
Hagmann, William K.
VLA-4 is implicated in several inflammatory and autoimmune disease states. A series of cyclic β-amino acids (β-aa) was studied as VLA-4 antagonists. Binding affinity was highly dependent on the dihedral angle (φ{symbol}) between the amino and the carboxyl
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