
Chemical and Pharmaceutical Bulletin p. 1335 - 1336 (1998)
Update date:2022-08-05
Topics:
Matsushima, Tomohiro
Mori, Michiko
Nakajima, Noriyuki
Maeda, Hiroshi
Uenishi, Jun-Ichi
Yonemitsu, Osamu
The C1 - C7 fragment (4) of tedanolide (1) was synthesized starting from methyl (R)-3-hydroxy-2-methyl-propionate via a mismatched but highly efficient sharpless dihydroxylation of the C1 - C7 α,β-unsaturated ester (6) with AD-mix-α.
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