Synthetic studies of 18-membered antitumor macrolide, tedanolide. 2. Stereoselective synthesis of the C1 - C7 fragment via a mismatched but highly efficient sharpless dihydroxylation

Article abstract of DOI:10.1248/cpb.46.1335

The C1 - C7 fragment (4) of tedanolide (1) was synthesized starting from methyl (R)-3-hydroxy-2-methyl-propionate via a mismatched but highly efficient sharpless dihydroxylation of the C1 - C7 α,β-unsaturated ester (6) with AD-mix-α.

Full text of DOI:10.1248/cpb.46.1335

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