Synthesis of enantiomerically pure backbone alkyl substituted peptide nucleic acids utilizing the Et-DuPHOS-Rh+ hydrogenation of enamido esters

Article abstract of DOI:10.1016/S0040-4039(99)00518-3

A series of enantiomerically pure alkyl substituted peptide nucleic acid (PNA) monomers were synthesized by incorporating novel α-amino acids produced by the Et-DuPHOS-Rh⁺ catalytic asymmetric hydrogenation of enamido esters.