Synthetic studies towards ML-3000: A concise synthesis of this non- steroidal anti-inflammatory drug

Article abstract of DOI:10.1016/S0040-4020(99)00176-3

ML-3000 was obtained from 1-chloro-3-phenyl-2-propyne in 8 steps with an overall yield of 19%. The key steps are a thermal acid-promoted bicyclization of an ω-acetylenic amino ester and a Suzuki cross-coupling reaction between a heteroaryl triflate and (4-chlorophenyl)boronic acid.