Asymmetric cyclopropanation of ketene silyl acetal with allylic acetate catalyzed by a palladium complex

Article abstract of DOI:10.1016/S0040-4039(99)00582-1

The first asymmetric cyclopropanation of ketene silyl acetal with allylic acetate was achieved. New chiral oxazolidinylpyrazole ligands and their η³-allylpalladium complexes were synthesized. Reaction of cinnamyl acetate with ketene silyl acetal of ethyl isobutylate in the presence of a palladium complex gave a phenyl cyclopropane derivative in 20~ 54%ee.