A catalytic asymmetric synthesis of a versatile intermediate for phorbol derivatives

Article abstract of DOI:10.1016/S0040-4039(99)00340-8

A catalytic asymmetric cyclopropanation of enol silyl ether 9 gave the lactone 3 in up to 78% ee. The lactone 3 was then transformed into 2, potentially a very versatile intermediate for phorbol analogs, using an intramolecular nitrile oxide cycloaddition as a key step.