Inhibition of human leukocyte elastase by N-substituted peptides containing α,α-difluorostatone residues at P1

Article abstract of DOI:10.1021/jm00104a004

A series of tripeptides which contain α,α-difluorostatone residues at P₁-P₁' and span the S₃-S₁' subsites have been shown to be potent inhibitors of human leukocyte elastase (HLE). The tripeptides described cont