Journal of Medicinal Chemistry p. 4795 - 4808 (1992)
Update date:2022-08-03
Topics: Peptide Synthesis Kinetic Analysis Enzyme assay Inhibition Human leukocyte elastase N-substituted peptides α,α-difluorostatone residues P1
Skiles
Miao
Sorcek
Jacober
Mui
Chow
Weldon
Possanza
Skoog
Keirns
Letts
Rosenthal
A series of tripeptides which contain α,α-difluorostatone residues at P1-P1' and span the S3-S1' subsites have been shown to be potent inhibitors of human leukocyte elastase (HLE). The tripeptides described cont
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Doi:10.1248/cpb.17.467
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