A simple synthesis of 3-phosphonyl-4-aminoquinolines from β- enaminophosphonates

Article abstract of DOI:10.1016/S0040-4020(99)00257-4

An easy and efficient synthesis of 4-aminoquinolines substituted with a phosphorylated group or a phosphine oxide group in the 3-position is described. The key step is a regioselective addition of lithiated β-enamino phosphonates to isocyanates to give fu