Bioorganic and Medicinal Chemistry Letters p. 1185 - 1188 (1999)
Update date:2022-08-03
Topics:
Beck, James P.
Curry, Matt A.
Chorvat, Robert J.
Fitzgerald, Larry W.
Gilligan, Paul J.
Zaczek, Robert
Trainor, George L.
A series of thiazolo[4,5-d]pyrimidine thiones and -ones was prepared and discovered to have good binding affinity to the CRH-R1 receptor, thus showing promise as a new class of potential anxiolytics and/or antidepressants.
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Doi:10.1002/jps.2600580427
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