Bioorganic and Medicinal Chemistry Letters p. 1167 - 1170 (1999)
Update date:2022-08-05
Topics:
Carter, Jeffery S.
Rogier
Graneto, Matthew J.
Seibert, Karen
Koboldt, Carol M.
Zhang, Yan
Talley, John J.
A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition.
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Doi:10.1007/BF01151460
()Doi:10.1021/jo00800a009
(1971)Doi:10.1246/cl.1988.1915
(1988)Doi:10.1021/ja01493a070
(1960)Doi:10.1007/BF00903493
(1963)Doi:10.1021/jm901577g
(2010)
