Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors

DOI: 10.1016/S0960-894X(99)00158-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1167 - 1170 (1999)

Update date:2022-08-05

Topics:

Authors:

Carter, Jeffery S.

Rogier Rogier

Graneto, Matthew J.

Seibert, Karen

Koboldt, Carol M.

Zhang, Yan

Talley, John J.

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Article abstract of DOI:10.1016/S0960-894X(99)00158-4

A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition.

Full text of DOI:10.1016/S0960-894X(99)00158-4

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