Synthesis of 2'-amino-3'-methoxyflavone (PD 98059)

Article abstract of DOI:10.1080/00397919908086149

2'-Amino-3'-methoxyflavone selectively blocks the activity of MAP kinase kinase (MEK) by inhibiting the activation of MAP kinase. This paper reports a straightforward synthesis of PD 98059 and 2-tert-butyl-8-methoxy-1,4-dihydro- quinolin-4-one.

Full text of DOI:10.1080/00397919908086149

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Synthetic Communications: An
International Journal for Rapid
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Organic Chemistry
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Synthesis Of 2'-Amino-3'-
Methoxyflavone (Pd 98059)
Siavosh Mahboobi a & Herwig Pongratz a
a Institute of Pharmacy, University of Regensburg,
D-93040, Regensburg, Germany
Published online: 17 Sep 2007.
To cite this article: Siavosh Mahboobi & Herwig Pongratz (1999): Synthesis Of 2'-
Amino-3'-Methoxyflavone (Pd 98059), Synthetic Communications: An International
Journal for Rapid Communication of Synthetic Organic Chemistry, 29:10, 1645-1652
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