Nucleosides and Nucleotides p. 493 - 508 (1999)
Update date:2022-07-31
Topics:
Verheijen, Jeroen C.
Van Roon, Anne-Marie M.
Van Der Laan, Alexander C.
Van Der Marel, Gijsbert A.
Van Boom, Jacques H.
The synthesis and evaluation of DNA-(3')-PNA chimeras containing rigid linkers based on (R/S)-4-hydroxy-D/L-proline are described. It is shown that installment of the trans-L-linker using the tetrabutylammonium salt of (R)- 4-(4,4'-dimethoxytrityloxy)-N-(thymin-l-yl)acetyl-L-proline (2) leads to a DNA-(3')-PNA chimera which hybridizes efficiently with complementary RNA.
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(1982)