Synthesis of DNA-(3')-PNA chimeras with conformationally restricted linkers based on 4-hydroxyproline

Article abstract of DOI:10.1080/15257779908043093

The synthesis and evaluation of DNA-(3')-PNA chimeras containing rigid linkers based on (R/S)-4-hydroxy-D/L-proline are described. It is shown that installment of the trans-L-linker using the tetrabutylammonium salt of (R)- 4-(4,4'-dimethoxytrityloxy)-N-(thymin-l-yl)acetyl-L-proline (2) leads to a DNA-(3')-PNA chimera which hybridizes efficiently with complementary RNA.

Full text of DOI:10.1080/15257779908043093

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Synthesis of DNA-(3′)-PNA Chimeras with
Conformationally Restricted Linkers
Based on 4-Hydroxyproline
Jeroen C. Verheijen a , Anne-Marie M. van Roon a , Alexander C. van
der Laan a , Gijsbert A. van der Marel a & Jacques H. van Boom a
a Leiden Institute of Chemistry, Gorlaeus Laboratories , PO Box 9502,
2300, RA, Leiden, The Netherlands
Published online: 04 Oct 2006.
To cite this article: Jeroen C. Verheijen , Anne-Marie M. van Roon , Alexander C. van der Laan ,
Gijsbert A. van der Marel & Jacques H. van Boom (1999) Synthesis of DNA-(3′)-PNA Chimeras with
Conformationally Restricted Linkers Based on 4-Hydroxyproline, Nucleosides and Nucleotides, 18:3,
493-508, DOI: 10.1080/15257779908043093
To link to this article: http://dx.doi.org/10.1080/15257779908043093
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