Chemical and Pharmaceutical Bulletin p. 1097 - 1100 (2000)
Update date:2022-08-03
Topics:
Takeda, Sunao
Kaneko, Yasushi
Eto, Hiromichi
Tokizawa, Minoru
Sato, Susumu
Yoshida, Kouiti
Namiki, Setsuo
Ogawa, Masaki
The α, α-gem-difluorination of 2',4'-difluoro- α(methylthio)acetophenone (1a) with N-fluoropyridinium salts gave 2',4',α-tetrafluoro-α-(methylthio)acetophenone (3a). This reaction was accelerated by the addition of zinc chloride, zinc bromide or anhydrous iron(III) chloride, and higher yields than the reaction without additives were obtained. The gem- difluorination reaction using FP-T300 in the presence of zinc bromide was applicable to other α-(alkylthio)acetophenone derivatives (1).
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